Rats! “Relevant” Chemical Exposures Are Not Relevant

news_views_icon“Close Enough For NIEHS Work,” By Steve Hentges.labrat_150
The subject of endocrine disruption is not particularly new, with extensive scientific and regulatory attention to endocrine disrupting chemicals (EDCs) over the last 20 years or so. … Quite a few natural and synthetic chemicals exhibit endocrine activity but, in spite of 20 years of research, the field of endocrine disruption continues to be ill-defined and highly controversial.  Two of the current controversies revolve around the related concepts of low-dose effects and non-monotonic dose response curves (NMDRC). In the field of toxicology, a bedrock principle is that “the dose makes the poison,” meaning that a toxicological response is generally expected to increase (or decrease) monotonically with increasing dose.  Read more.

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